解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:This study aimed at reseaching the immune effect of porcine circovirus type 2 (PCV2) DNA vaccine containing CpG motif on mice. METHODS:A total of 40 6-week-old female BALB/c mice were randomly divided into four groups which were immunized by 18CpG-pVAX1-ORF2, pVAX1-ORF2, pVAX1 and PBS, respectively, and imm...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-016-0597-0
更新日期:2016-11-14 00:00:00
abstract:BACKGROUND:Taiwan has been considered free from canine parvovirus type 2c (CPV-2c) based on the last report of canine parvovirus type 2 (CPV-2) surveillance. However, since January 2015, the first report of CPV-2c in a puppy has occurred in Taiwan. There is currently limited information about the CPV-2c variant in Taiw...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-016-0620-5
更新日期:2016-09-23 00:00:00
abstract:BACKGROUND:About half of the world's population are living in the endemic area of dengue viruses implying that a rapid-mass vaccination may be required. In addition, a major target of dengue vaccine are children, thus, a needle-free administration is more attractive. These problems may be overcome by the alternative ro...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-016-0598-z
更新日期:2016-08-18 00:00:00
abstract:BACKGROUND:Aedes aegypti is a competent arthropod vector of chikungunya virus (CHIKV). The rate at which the virus disseminate in the vector is limited by temperature of their environment which can be an important determinant of geographical and seasonal limits to transmission by the arthropods in the tropics. This stu...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-016-0566-7
更新日期:2016-06-29 00:00:00
abstract:BACKGROUND:West Nile virus (WNV) is an emerging zoonotic pathogen which is harmful to human and animal health. Effective vaccination in susceptible hosts should protect against WNV infection and significantly reduce viral transmission between animals and from animals to humans. A versatile vaccine suitable for differen...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-016-0568-5
更新日期:2016-06-24 00:00:00
abstract:BACKGROUND:Japanese encephalitis virus (JEV) is a mosquito-borne flavivirus that causes acute viral encephalitis in humans. Pigs are important amplifier hosts of JEV. Emerging evidence indicates that host microRNAs (miRNAs) play key roles in modulating viral infection and pathogenesis. However, mechanistic studies deli...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-016-0562-y
更新日期:2016-06-21 00:00:00
abstract:BACKGROUND:RNA viruses are characterized by high rate of mutations mainly due to the lack of proofreading repair activities associated with its RNA-dependent RNA-polymerase (RdRp). In case of arboviruses, this phenomenon has lead to the existence of mixed population of genomic variants within the host called quasi-spec...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-016-0543-1
更新日期:2016-06-02 00:00:00
abstract:BACKGROUND:Human noroviruses (NoVs) are the main cause of gastroenteritis worldwide. The most commonly detected NoV strains belong to the genetically diverse GII.4 genotype, with new pandemic variants emerging periodically. Despite extensive efforts, NoV investigation has been hampered by the lack of an effective in vi...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-016-0538-y
更新日期:2016-05-21 00:00:00
abstract:BACKGROUND:Porcine epidemic diarrhea virus (PEDV) is the main causative agent of porcine epidemic diarrhea (PED). Since December 2010, a large-scale outbreak of diarrhea has been observed in swine farms in China. Accumulated evidence indicates that this large-scale outbreak of diarrhea were caused by highly virulent PE...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-016-0529-z
更新日期:2016-04-22 00:00:00
abstract:BACKGROUND:To assess the potential effects of telbivudine (LdT) and entecavir (ETV) on renal function in patients with chronic hepatitis B (CHB), we performed a meta-analysis of the relevant data available on these agents to evaluate their effects on the estimated glomerular filtration rate (eGFR) during treatment. ME...
journal_title:Virology journal
pub_type: 杂志文章,meta分析,评审
doi:10.1186/s12985-016-0522-6
更新日期:2016-04-09 00:00:00
abstract:BACKGROUND:Brevicoryne brassicae virus (BrBV) is a positive-strand genomic RNA virus which is unassigned tentative member of the genus Iflavirus. BrBv was first identified and characterized in the late 90's in the cabbage aphid in the United Kingdom (UK) (J Gen Virol 88:2590-2595, 2007) and was fully sequenced, using r...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-016-0500-z
更新日期:2016-03-22 00:00:00
abstract:BACKGROUND:An extensive outbreak of equine influenza occurred across multiple countries in South America during 2012. The epidemic was first reported in Chile then spread to Brazil, Uruguay and Argentina, where both vaccinated and unvaccinated animals were affected. In Brazil, infections were widespread within 3months ...
journal_title:Virology journal
pub_type: 历史文章,杂志文章
doi:10.1186/s12985-016-0503-9
更新日期:2016-03-19 00:00:00
abstract:BACKGROUND:Mumps virus is a negative-sense, single stranded RNA virus consisting of a ribonucleocapsid core enveloped by a lipid membrane derived from host cell, which causes mumps disease preventable by vaccination. Since virus lipid envelope and glycosylation pattern are not encoded by the virus but dependent on the ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-016-0463-0
更新日期:2016-01-14 00:00:00
abstract::Bats have been recognized as the natural reservoirs of a large variety of viruses. Special attention has been paid to bat coronaviruses as the two emerging coronaviruses which have caused unexpected human disease outbreaks in the 21st century, Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and Middle East Re...
journal_title:Virology journal
pub_type: 杂志文章,评审
doi:10.1186/s12985-015-0422-1
更新日期:2015-12-22 00:00:00
abstract:BACKGROUND:Influenza virus infections are responsible for significant morbidity worldwide and therefore it remains a high priority to develop more broadly protective vaccines. Adjuvation of current seasonal influenza vaccines has the potential to achieve this goal. METHODS:To assess the immune potentiating properties ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-015-0435-9
更新日期:2015-12-08 00:00:00
abstract:BACKGROUND:The UL54 protein of Duck Enteritis Virus (DEV) is a homolog of herpes simplex virus-1 (HSV-1) immediate-early infectious cell protein 27 (ICP27), a multifunctional protein essential for viral infection. Nonetheless, there is little information on the UL54 protein of DEV. METHODS:The UL54 gene was cloned int...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-015-0424-z
更新日期:2015-11-25 00:00:00
abstract:BACKGROUND:Human enterovirus (EV) and parechovirus (HPeV) are significant causes of encephalitis and meningitis in children. The aim of this study was to determine the prevalence, type and viral RNA concentration of EV and HPeV in cerebrospinal fluid (CSF) samples in an unselected cohort of patients <18 years admitted ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-015-0427-9
更新日期:2015-11-25 00:00:00
abstract:BACKGROUND:Genome-wide RNAi screening has been widely used to identify host proteins involved in replication and infection of different viruses, and numerous host factors are implicated in the replication cycles of these viruses, demonstrating the power of this approach. However, discrepancies on target identification ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-015-0420-3
更新日期:2015-11-24 00:00:00
abstract:BACKGROUND:Infection by any one of 15 high risk human papillomavirus (hrHPV) types causes most invasive cervical cancers. Their oncogenic genome is encapsidated by L1 (major) and L2 (minor) coat proteins. Current HPV prophylactic vaccines are composed of L1 virus-like particles (VLP) that elicit type restricted immunit...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-015-0364-7
更新日期:2015-09-11 00:00:00
abstract:BACKGROUND:Norovirus (NoV) has been recognized as the leading cause of both outbreaks and sporadic cases of acute gastroenteritis in children and adults worldwide. Stool samples collected from outpatients with clinical symptoms of acute gastroenteritis in all age groups at the First People's Hospital in Huzhou, Huzhou,...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-015-0370-9
更新日期:2015-09-11 00:00:00
abstract:BACKGROUND:Since avian-origin H3N2 canine influenza virus (CIV) was first identified in South Korea in 2008, the novel influenza virus has been reported in several countries in Asia. Reverse zoonotic transmission of pandemic H1N1 (2009) influenza virus (pH1N1) has been observed in a broad range of animal species. Viral...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-015-0343-z
更新日期:2015-09-04 00:00:00
abstract:BACKGROUND:Highly pathogenic avian influenza virus (AIV) subtype H5N1 remains a threat to poultry. Duck enteritis virus (DEV)-vectored vaccines expressing AIV H5N1 hemagglutinin (HA) may be viable AIV and DEV vaccine candidates. METHODS:To facilitate the generation and further improvement of DEV-vectored HA(H5) vaccin...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-015-0354-9
更新日期:2015-08-13 00:00:00
abstract:BACKGROUND:In mammals, interleukin 2 (IL-2) has been shown to decrease replication or attenuate pathogenicity of numerous viral pathogens (herpes simplex virus, vaccinia virus, human respiratory syncytial virus, human immunodeficiency virus) by activating natural killer cells (NK), cytotoxic T lymphocytes and expanding...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-015-0353-x
更新日期:2015-08-08 00:00:00
abstract:BACKGROUND:Porcine circovirus type-2b (PCV2b) is recognized as the etiological agent of the various clinical manifestations of porcine circovirus-associated disease (PCVAD). Previous studies have demonstrated effectiveness of chimeric PCV1-2 vaccines against PCV2b challenge. In this study, the efficacy of inactivated a...
journal_title:Virology journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12985-015-0338-9
更新日期:2015-07-30 00:00:00
abstract:BACKGROUND:In adenoviruses, primary host cell recognition is generally performed by the head domains of their homo-trimeric fibre proteins. This first interaction is reversible. A secondary, irreversible interaction subsequently takes place via other adenovirus capsid proteins and leads to a productive infection. Altho...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-015-0309-1
更新日期:2015-05-22 00:00:00
abstract:BACKGROUND:A novel reassortant H7N9 influenza A virus has crossed the species barrier from poultry to cause human infections in China in 2013 and 2014. Rapid detection of the novel H7N9 virus is important to detect this virus in poultry and reduce the risk of an epidemic in birds or humans. FINDINGS:In this study, a m...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-015-0300-x
更新日期:2015-04-30 00:00:00
abstract:BACKGROUND:Although prophylactic vaccines have been developed against HPV6, HPV11, HPV16 and HPV18 there is the clear unmet medical need in order to justify the development of drugs targeting human papillomavirus replication. The native host cells of HPVs are human primary keratinocytes which can be cultivated in raft ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-015-0292-6
更新日期:2015-04-14 00:00:00
abstract:BACKGROUND:The plateau pika (Ochotona curzoniae) is a small rabbit-like mammal that lives at high altitudes in the Qinghai-Tibet plateau and is in close contact with birds. Following the outbreak of highly pathogenic avian influenza (HPAI) H5N1 during 2005 in the migratory birds of Qinghai Lake, two clades of H5N1 have...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-015-0290-8
更新日期:2015-04-14 00:00:00
abstract:BACKGROUND:In South Korea, about 20 types of antiretroviral drugs are used in the treatment of patients with human immunodeficiency virus/acquired immune deficiency syndrome. Since 2010, raltegravir, etravirine, and darunavir have been spotlighted as new drugs for highly active antiretroviral therapy (HAART)-experience...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-015-0283-7
更新日期:2015-04-09 00:00:00
abstract:BACKGROUND:Tomato yellow leaf curl virus (TYLCV), a monopartite begomovirus (family Geminiviridae) is responsible for heavy yield losses for tomato production around the globe. In Oman at least five distinct begomoviruses cause disease in tomato, including TYLCV. Unusually, TYLCV infections in Oman are sometimes associ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-015-0263-y
更新日期:2015-03-04 00:00:00
abstract:BACKGROUND:Recently, a new subset of CD4(+)T helper cell termed Follicular helper T cells (Tfh), which play a pivotal role in B cell activation and differentiation in lymphoid structures, has been reported to participate in some certain autoimmune diseases. But whether Tfh cells are involved in the pathogenesis of VMC ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-015-0257-9
更新日期:2015-02-11 00:00:00
abstract:BACKGROUND:Dengue has emerged as the most significant of arboviral diseases in the 21st century. It is endemic to >100 tropical and sub-tropical countries around the world placing an estimated 3.6 billion people at risk. It is caused by four genetically similar but antigenically distinct, serotypes of dengue viruses. T...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-015-0248-x
更新日期:2015-02-08 00:00:00
abstract:BACKGROUND:The human polyomavirus BK expresses a 66 amino-acid peptide referred to as agnoprotein. Though mutants lacking agnoprotein are severely reduced in producing infectious virions, the exact function of this peptide remains incompletely understood. To elucidate the function of agnoprotein, we searched for novel ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-014-0220-1
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:With the clinical development of several antiviral intervention strategies for influenza, it becomes crucial to explore viral load shedding in the nasal cavity as a biomarker for treatment success, but also to explore sampling strategies for sensible and reliable virus collection. FINDINGS:In this study, 24...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-014-0233-9
更新日期:2014-12-24 00:00:00
abstract:BACKGROUND:Production of cassava (Manihot esculenta Crantz), a food security crop in sub-Saharan Africa, is threatened by the spread of cassava brown streak disease (CBSD) which manifests in part as a corky necrosis in the storage root. It is caused by either of two virus species, Cassava brown streak virus (CBSV) and ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-014-0216-x
更新日期:2014-12-20 00:00:00
abstract:BACKGROUND:The avian influenza virus (AIV) causes frequent disease with high morbidity and mortality. RNA interference (RNAi) has been shown to provide an effective antiviral defense in animals, and several studies have focused on harnessing small interfering RNAs (siRNAs) to inhibit viral infections. In addition, sing...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-014-0208-x
更新日期:2014-11-29 00:00:00
abstract:BACKGROUND:Cell culture adaptation of very virulent infectious bursal disease virus (vvIBDV) was shown to be mainly associated with the VP2 capsid protein residues 253, 279, and 284. The single mutation A284T proved critical for cell culture tropism, but did not confer efficient virus replication, which at least requir...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-014-0199-7
更新日期:2014-11-25 00:00:00
abstract:BACKGROUND:Data about molecular diversity of commonly circulating type A influenza viruses in Ontario swine are scarce. Yet, this information is essential for surveillance of animal and public health, vaccine updates, and for understanding virus evolution and its large-scale spread. METHODS:The study population consis...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-014-0194-z
更新日期:2014-11-22 00:00:00
abstract:BACKGROUND:On 19 February 2013, the first patient infected with a novel influenza A H7N9 virus from an avian source showed symptoms of sickness. More than 349 laboratory-confirmed cases and 109 deaths have been reported in mainland China since then. Laboratory-confirmed, human-to-human H7N9 virus transmission has not b...
journal_title:Virology journal
pub_type: 历史文章,杂志文章
doi:10.1186/1743-422X-11-185
更新日期:2014-11-03 00:00:00
abstract:BACKGROUND:It is becoming progressively more understandable that genetic variability of viruses is a major challenge in translating the laboratory findings to clinic. Genetic variability is the underlying cause of variant viral proteins which are not targetable by host immunological machinery. METHODS:500 patients wer...
journal_title:Virology journal
pub_type: 临床试验,杂志文章
doi:10.1186/1743-422X-11-171
更新日期:2014-09-30 00:00:00